Pyributicarb Inhibitor

Pyributicarb is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR).

Matsubara T, Noracharttiyapot W, Toriyabe T, et al. Assessment of Human Pregnane X Receptor Involvement in Pesticide-Mediated Activation of CYP3A4 Gene[J]. Drug Metabolism and Disposition, 2007, 35(5):728-733.
Matsubara T, Noracharttiyapot W, Toriyabe T, et al. Assessment of Human Pregnane X Receptor Involvement in Pesticide-Mediated Activation of CYP3A4 Gene[J]. Drug Metabolism and Disposition, 2007, 35(5):728-733.
Kojima H, Sata F, Takeuchi S,et al.Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays. Toxicology. 2011 Feb 27;280(3):77-87.
Kojima H, Sata F, Takeuchi S,et al.Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays. Toxicology. 2011 Feb 27;280(3):77-87.

Small volumes of Pyributicarb, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5758508 is an inhibitor targeting Pyributicarb.