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UBCS039 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5758570

MBS5758570 is an inhibitor targeting UBCS039. UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 uM) More details

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Product Documentation
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Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
UBCS039, Inhibitor
Full Product Name
UBCS039
Product Gene Name
UBCS039, inhibitor
Form/Format
Solid. Powder
Purity/Purification
99.75%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
247.29
Solubility
DMSO: 125mg/mL (505.48mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C16H13N3
SMILES
c1cncc(C2Nc3ccccc3-n3cccc32)c1
CAS Number
358721-70-7
Target & IC50
Sirt6: ic50 38uM

Product Categories/Family for UBCS039, inhibitor

Chromatin/Epigenetic; Sirtuin; DNA Damage/DNA Repair

Structure of UBCS039, inhibitor

UBCS039 Inhibitor – Cat# MBS5758570

Product References and Citations for UBCS039, inhibitor

Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells.[J]. Cell death & disease, 2018.
Weijie You, et al. Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules. Angew. Chem. Int. Ed. 2017, 56, 1007-1011.
Sara Iachettini, et al. Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells. Cell Death and Disease (2018) 9:996.

Other Notes

Small volumes of UBCS039, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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