(E/Z)-GSK5182 Inhibitor

Name: (E/Z)-GSK5182 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5758597
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5758597

(E/Z)-GSK5182 is a racemic compound of (E)-GSK5182 and (Z)-GSK5182 isomers. GSK5182 is a highly selective and orally active estrogen-related receptor gamma (ERRgamma) inverse agonist(IC50 of 79nM), and also induces reactive oxyen species (ROS) generation in… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

(E/Z)-GSK5182 ((E/Z)-GSK5182 ), Inhibitor

Full Product Name

(E/Z)-GSK5182

Product Gene Name

(E/Z)-GSK5182 , inhibitor

Product Synonym Names

(E/Z)-GSK5182; GSK5182(Z/E)

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

417.54

Solubility

DMSO: 95mg/mL (227.52mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C27H31NO3

SMILES

CN(C)CCOC1=CC=C(C=C1)C(=C(CCCO)C1=CC=CC=C1)C1=CC=C(O)C=C1

Target & IC50

ERRgamma
ROS

Product Categories/Family for (E/Z)-GSK5182 , inhibitor

Endocrinology/Hormones; Immunology/Inflammation

Product References and Citations for (E/Z)-GSK5182 , inhibitor

Misra J, et al. ERRgamma: a Junior Orphan with a Senior Role in Metabolism. Trends Endocrinol Metab. 2017 Apr;28(4):261-272.
Misra J, et al. ERRgamma: a Junior Orphan with a Senior Role in Metabolism. Trends Endocrinol Metab. 2017 Apr;28(4):261-272.
Kim DK, et al. Inverse agonist of nuclear receptor ERRgamma mediates antidiabetic effect through inhibition of hepatic gluconeogenesis. Diabetes. 2013 Sep;62(9):3093-102.
Kim DK, et al. Inverse agonist of nuclear receptor ERRgamma mediates antidiabetic effect through inhibition of hepatic gluconeogenesis. Diabetes. 2013 Sep;62(9):3093-102.
Kim JH, et al. Estrogen-related receptor gamma is upregulated in liver cancer and its inhibition suppresses livercancer cell proliferation via induction of p21 and p27. Exp Mol Med. 2016 Mar 4;48:e213.
Kim JH, et al. Estrogen-related receptor gamma is upregulated in liver cancer and its inhibition suppresses livercancer cell proliferation via induction of p21 and p27. Exp Mol Med. 2016 Mar 4;48:e213.

Other Notes

Small volumes of (E/Z)-GSK5182 , inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for (E/Z)-GSK5182 purchase

MBS5758597 is an inhibitor targeting (E/Z)-GSK5182 . Also known as (E/Z)-GSK5182.