Albaconazole Inhibitor

Albaconazole is a 14alpha-Demethylase inhibitor. It potentially for the treatment,of fungal infection.

Dietz AJ, Barnard JC, van Rossem K. A randomized, double-blind, multiple-dose, placebo-controlled, dose escalation study with a 3-cohort parallel group design to investigate the tolerability and pharmacokinetics of albaconazole in healthy subjects. Clin Pharmacol Drug Dev. 2014 Jan;3(1):25-33. doi: 10.1002/cpdd.72. PubMed PMID: 27128227.
Sigurgeirsson B, van Rossem K, Malahias S, Raterink K. A phase II, randomized, double-blind, placebo-controlled, parallel group, dose-ranging study to investigate the efficacy and safety of 4 dose regimens of oral albaconazole in patients with distal subungual onychomycosis. J Am Acad Dermatol. 2013 Sep;69(3):416-25. doi: 10.1016/j.jaad.2013.03.021. PubMed PMID: 23706639.
Guillon R, Pagniez F, Picot C, Hedou D, Tonnerre A, Chosson E, Duflos M, Besson T, Loge C, Le Pape P. Discovery of a novel broad-spectrum antifungal agent derived from albaconazole. ACS Med Chem Lett. 2013 Jan 17;4(2):288-92. doi: 10.1021/ml300429p. PubMed PMID: 24900660; PubMed Central PMCID: PMC4027234.
van Rossem K, Lowe JA. A Phase 1, randomized, open-label crossover study to evaluate the safety and pharmacokinetics of 400 mg albaconazole administered to healthy participants as a tablet formulation versus a capsule formulation. Clin Pharmacol. 2013;5:23-31. doi: 10.2147/CPAA.S39600. PubMed PMID: 23390369; PubMed Central PMCID: PMC3564460.

Small volumes of Albaconazole, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5758609 is an inhibitor targeting Albaconazole.