Se-Methylselenocysteine Inhibitor

Se-Methylselenocysteine is a drug potentially for the treatment,of solid tumors. Se-Methylselenocysteine exerts pro-apoptosis effects through increasing Cx43 expression, which in turn down-regulates Bcl-2 and up-regulates bad expression. Se-methylselenocysteine offers selective protection against organ-specific toxicity induced by clinically active agents and enhances further antitumor activity, resulting in an improved therapeutic index.

Yao Z, Zhang Y, Li H, Deng Z, Zhang X. Synergistic effect of Se-methylselenocysteine and vitamin E in ameliorating the acute ethanol-induced oxidative damage in rat. J Trace Elem Med Biol. 2015 Jan;29:182-7. doi: 10.1016/j.jtemb.2014.08.004. PubMed PMID: 25213679.
Yang H, Jia X. Safety evaluation of Se-methylselenocysteine as nutritional selenium supplement: acute toxicity, genotoxicity and subchronic toxicity. Regul Toxicol Pharmacol. 2014 Dec;70(3):720-7. doi: 10.1016/j.yrtph.2014.10.014. PubMed PMID: 25444999.
Avila FW, Yang Y, Faquin V, Ramos SJ, Guilherme LR, Thannhauser TW, Li L. Impact of selenium supply on Se-methylselenocysteine and glucosinolate accumulation in selenium-biofortified Brassica sprouts. Food Chem. 2014 Dec 15;165:578-86. doi: 10.1016/j.foodchem.2014.05.134. PubMed PMID: 25038715.
Cao S, Durrani FA, Toth K, Rustum YM. Se-methylselenocysteine offers selective protection against toxicity and potentiates the antitumour activity of anticancer drugs in preclinical animal models. Br J Cancer. 2014 Apr 2;110(7):1733-43. doi: 10.1038/bjc.2014.85. PubMed PMID: 24619073; PubMed Central PMCID: PMC3974093.

Small volumes of Se-Methylselenocysteine, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5758611 is an inhibitor targeting Se-Methylselenocysteine.