Aminopterin Inhibitor

Name: Aminopterin Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5758614
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5758614

Aminopterin is a synthetic folic acid derivative whose metabolite is a competitive inhibitor of dihydrofolate reductase More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Aminopterin, Inhibitor

Full Product Name

Aminopterin

Product Synonym Names

4-Aminofolic acid; APGA

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

440.41

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C19H20N8O5

SMILES

Nc1nc(N)c2nc(CNc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)cnc2n1

CAS Number

54-62-6

Target & IC50

Antifolate

In Vitro

Aminopterin has anticancer and immunosuppressive properties. Formulations containing it have been used for pediatric leukemia though methotrexate is now more commonly used due to a more favorable therapeutic index[1]

Product Categories/Family for Aminopterin, inhibitor

Cell Cycle/DNA Damage

Product References and Citations for Aminopterin, inhibitor

Cole, P. D. Phase II Trial of Oral Aminopterin for Adults and Children with Refractory Acute Leukemia[J]. Clinical Cancer Research, 2005, 11(22):8089-8096.
Cole, P. D. Phase II Trial of Oral Aminopterin for Adults and Children with Refractory Acute Leukemia[J]. Clinical Cancer Research, 2005, 11(22):8089-8096.
Littlefield, J. W. Selection of Hybrids from Matings of Fibroblasts in vitro and Their Presumed Recombinants[J]. Science, 1964, 145(3633):709-710.
Littlefield, J. W. Selection of Hybrids from Matings of Fibroblasts in vitro and Their Presumed Recombinants[J]. Science, 1964, 145(3633):709-710.

Other Notes

Small volumes of Aminopterin, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Aminopterin purchase

MBS5758614 is an inhibitor targeting Aminopterin.