ADH-503 Inhibitor

Name: ADH-503 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5758643
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5758643

ADH-503 is a potent agonist of the integrin CD11b to mitigate myeloid cell immunosuppression. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ADH-503, Inhibitor

Full Product Name

ADH-503

Product Gene Name

ADH-503, inhibitor

Form/Format

Solid. Powder

Purity/Purification

100.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

524.70

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C27H28N2O5S2

SMILES

C[N+](C)(C)CCO.[O-]C(=O)c1ccc(cc1)-c1ccc(\C=C2/SC(=S)N(Cc3ccccc3)C2=O)o1

CAS Number

2055362-74-6

Target & IC50

CD11b

In Vitro

ADH-503 had the mean half-life of 4.68 and 3.95 hours, a maximum concentration of 1716 and 2594ng/mL and AUC0-t in the plasma of 6950 and 13962 ng.h/mL at 30 and 100mg/kg dosing, respectively.

Product Categories/Family for ADH-503, inhibitor

Immunology/Inflammation

Product References and Citations for ADH-503, inhibitor

Roheena Z Panni, John M Herndon, Chong Zuo,et al. Agonism of CD11b Reprograms Innate Immunity to Sensitize Pancreatic Cancer to Immunotherapies.Sci Transl Med. 2019 Jul 3;11(499):eaau9240.
Panni RZ, et al. Agonism of CD11b reprograms innate immunity to sensitize pancreatic cancer to immunotherapies. Sci Transl Med. 2019 Jul 3;11(499).

Other Notes

Small volumes of ADH-503, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ADH-503 purchase

MBS5758643 is an inhibitor targeting ADH-503.