Iberdomide Inhibitor

Iberdomide is a modulator of cereblon(IC50 value of 60nM in a competitive TR-FRET assay).

Matyskiela M E, Zhang W, Man H W, et al. A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos[J]. Journal of Medicinal Chemistry, 2017:acs.jmedchem.6b01921.
Matyskiela M E, Zhang W, Man H W, et al. A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos[J]. Journal of Medicinal Chemistry, 2017:acs.jmedchem.6b01921.
Peter, H, Schafer, et al. Cereblon modulator iberdomide induces degradation of the transcription factors Ikaros and Aiolos: immunomodulation in healthy volunteers and relevance to systemic lupus erythematosus.[J]. Annals of the Rheumatic Diseases, 2017.
Peter, H, Schafer, et al. Cereblon modulator iberdomide induces degradation of the transcription factors Ikaros and Aiolos: immunomodulation in healthy volunteers and relevance to systemic lupus erythematosus.[J]. Annals of the Rheumatic Diseases, 2017.

Small volumes of Iberdomide, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5758657 is an inhibitor targeting Iberdomide.