Tasosartan Inhibitor

Name: Tasosartan Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5758663
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5758663

Tasosartan is an antagonist of angiotensin II type 2 (AT2) receptor (IC50 = 1.2nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Tasosartan, Inhibitor

Full Product Name

Tasosartan

Product Synonym Names

WAY-ANA 756

Form/Format

Solid. Powder

Purity/Purification

98.93%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

411.46

Solubility

DMSO: 125mg/mL (303.80mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C23H21N7O

SMILES

Cc1nc(C)c2c(n1)N(Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)C(=O)CC2

CAS Number

145733-36-4

Target & IC50

angiotensin II type 2 (AT2) receptor: ic50 1.2nM

In Vitro

In vivo, tasosartan (p.o. or i.v.) blocked by 80% AT1 receptors 1 to 2 h after drug administration and still had a 40% effect at 32 hours.

Product Categories/Family for Tasosartan, inhibitor

Endocrinology/Hormones; RAAS

Product References and Citations for Tasosartan, inhibitor

Maillard MP, et al. Tasosartan, enoltasosartan, and angiotensin II receptor blockade: the confounding role of protein binding. J Pharmacol Exp Ther. 2000 Nov;295(2):649-54.
Maillard M P, Rossat J, Brunner H R, et al. Tasosartan, enoltasosartan, and angiotensin II receptor blockade: The confounding role of protein binding[J]. Journal of Pharmacology & Experimental Therapeutics, 2000, 295(2):649-654.
Maillard M P, Rossat J, Brunner H R, et al. Tasosartan, enoltasosartan, and angiotensin II receptor blockade: The confounding role of protein binding[J]. Journal of Pharmacology & Experimental Therapeutics, 2000, 295(2):649-654.
Elokdah HM, et al. Novel human metabolites of the angiotensin-II antagonist Tasosartan and their pharmacological effects. Bioorg Med Chem Lett. 2002 Aug 5;12(15):1967-71.
Ellingboe J W, Collini M D, Quagliato D, et al. Metabolites of the Angiotensin II Antagonist Tasosartan: The Importance of a Second Acidic Group[J]. journal of medicinal chemistry, 1998, 41(22):4251-4260.
Ellingboe J W, Collini M D, Quagliato D, et al. Metabolites of the Angiotensin II Antagonist Tasosartan: The Importance of a Second Acidic Group[J]. journal of medicinal chemistry, 1998, 41(22):4251-4260.

Other Notes

Small volumes of Tasosartan, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Tasosartan purchase

MBS5758663 is an inhibitor targeting Tasosartan.