SB4 Inhibitor – Sb 4

Name: SB4 Inhibitor; Sb 4; MyBioSource
Brand: MyBioSource
SKU: MBS5758665
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5758665

SB 4 is an agonist of benzoxazole bone morphogenetic protein (BMP) signaling (EC50 :74nM) More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SB 4 (SB4), Inhibitor

Full Product Name

SB 4

Product Gene Name

SB4, inhibitor

Form/Format

Solid. Powder

Purity/Purification

99.24%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

320.20

Solubility

DMSO: 125mg/mL (390.38mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C14H10BrNOS

SMILES

Brc1ccc(CSc2nc3ccccc3o2)cc1

CAS Number

100874-08-6

Target & IC50

BMP: ic50 74nM (EC50)

In Vitro

SB4, that rapidly stimulated BMP signaling in these cells. Activation of BMP signaling by sb4 increased the phosphorylation of key second messengers (SMAD-1/5/9) and also increased expression of direct target genes (inhibitors of DNA binding, Id1 and Id3) in canonical BMP signaling[1].

Product Categories/Family for SB4, inhibitor

TGF-beta/Smad

Product References and Citations for SB4, inhibitor

Bradford S T J, Ranghini E J, Grimley E, et al. High-throughput screens for agonists of bone morphogenetic protein (BMP) signaling identify potent benzoxazole compounds[J]. Journal of Biological Chemistry, 2019.

Other Notes

Small volumes of SB4, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SB4 purchase

MBS5758665 is an inhibitor targeting SB4. Also known as SB 4.