Nitecapone Inhibitor

Name: Nitecapone Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5758695
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5758695

Nitecapone is a reversible inhibitor of S-COMT (IC50 values of 300nM in rat liver) More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Nitecapone, Inhibitor

Full Product Name

Nitecapone

Form/Format

Solid. Powder

Purity/Purification

99.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

265.22

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C12H11NO6

SMILES

CC(=O)C(=Cc1cc(O)c(O)c([N+](=O)[O-])c1)C(C)=O

CAS Number

116313-94-1

Target & IC50

S-COMT: ic50 300nM

In Vitro

At highmicroMolar to millimolar concentrations In vitro research studies, nitecapone is an effective antioxidant, nitric oxide radical scavenger, and iron chelator that can protect cells from lipid peroxidation[1]

Product References and Citations for Nitecapone, inhibitor

P. T. Mannisto, Kaakkola S. Catechol-O-methyltransferase (COMT): Biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors[J]. Pharmacological Reviews, 2000, 51(4):593-628.
P. T. Mannisto, Kaakkola S. Catechol-O-methyltransferase (COMT): Biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors[J]. Pharmacological Reviews, 2000, 51(4):593-628.
Inhibitors of catechol-O-methyltransferase sensitize mice to pain[J]. British Journal of Pharmacology, 2010, 161(7).
Inhibitors of catechol-O-methyltransferase sensitize mice to pain[J]. British Journal of Pharmacology, 2010, 161(7).
Salmela K S, Roine R P, H K-Nikanne J, et al. Effect of Bismuth and Nitecapone on Acetaldehyde Production by Helicobacter pylori[J]. Scandinavian Journal of Gastroenterology, 1994, 29(6):528-531.

Other Notes

Small volumes of Nitecapone, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Nitecapone purchase

MBS5758695 is an inhibitor targeting Nitecapone.

Nitecapone Inhibitor

Product Overview

Structure of Nitecapone, inhibitor

Related Product Information for Nitecapone, inhibitor

Product References and Citations for Nitecapone, inhibitor

Other Notes

Searchable Terms for Nitecapone purchase