Aegeline Inhibitor

Aegeline is an alkaloidal-amide, isolated from the leaves of Aegle marmelos and have shown antihyperglycemic as well as antidyslipidemic activities in the validated animal models of type 2 diabetes mellitus.

Aegeline from Aegle marmelos stimulates glucose transport via Akt and Rac1 signaling, and contributes to a cytoskeletal rearrangement through PI3K/Rac1[J]. European Journal of Pharmacology, 2015, 762:419-429.
Aegeline from Aegle marmelos stimulates glucose transport via Akt and Rac1 signaling, and contributes to a cytoskeletal rearrangement through PI3K/Rac1[J]. European Journal of Pharmacology, 2015, 762:419-429.
Nugroho A E, Riyanto S, Sukari M A, et al. EFFECTS OF AEGELINE, A MAIN ALKALOID OF AEGLE MARMELOS CORREA LEAVES, ON THE HISTAMINE RELEASE FROM MAST CELLS[J]. Pakistan Journal of Pharmaceutical Sciences, 2011, 24(24):359-367.
Nugroho A E, Riyanto S, Sukari M A, et al. EFFECTS OF AEGELINE, A MAIN ALKALOID OF AEGLE MARMELOS CORREA LEAVES, ON THE HISTAMINE RELEASE FROM MAST CELLS[J]. Pakistan Journal of Pharmaceutical Sciences, 2011, 24(24):359-367.

Small volumes of Aegeline, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5758709 is an inhibitor targeting Aegeline.