PT-2385 Inhibitor

Name: PT-2385 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5758711
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5758711

MBS5758711 is an inhibitor targeting PT-2385. PT-2385 is a selective HIF-2alpha inhibitor (Kd More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PT-2385, Inhibitor

Full Product Name

PT-2385

Product Gene Name

PT-2385, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.91%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

383.34

Solubility

DMSO: 50mg/mL (130.43mM)
:
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C17H11F3NO4S

SMILES

N#CC1=CC(F)=CC(OC2=CC=C(S(=O)(C)=O)C3=C2CC(F)(F)[C@]3O)=C1

CAS Number

1672665-49-4

Target & IC50

HIF/HIF Prolyl-Hydroxylase

Product Categories/Family for PT-2385, inhibitor

Angiogenesis; Chromatin/Epigenetic

Product References and Citations for PT-2385, inhibitor

Eli Wallace, Ph.D. PT2385: HIF-2alpha Antagonist for the treatment,of VHL Mutant ccRCC. 12th International VHL Medical Symposium April 8, 2016.
Eli Wallace, Ph.D. PT2385: HIF-2alpha Antagonist for the treatment,of VHL Mutant ccRCC. 12th International VHL Medical Symposium April 8, 2016.
Xie C, et al. Activation of intestinal hypoxia-inducible factor 2alpha during obesity contributes to hepatic steatosis. Nat Med. 2017 Nov;23(11):1298-1308.
Wallace EM, et al. A Small-Molecule Antagonist of HIF2alpha Is Efficacious in Preclinical Models of Renal Cell Carcinoma. Cancer Res. 2016 Sep 15;76(18):5491-500.
Wallace EM, et al. A Small-Molecule Antagonist of HIF2alpha Is Efficacious in Preclinical Models of Renal Cell Carcinoma. Cancer Res. 2016 Sep 15;76(18):5491-500.

Other Notes

Small volumes of PT-2385, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

PT-2385 Inhibitor

Product Overview

Product Categories/Family for PT-2385, inhibitor

Structure of PT-2385, inhibitor

Related Product Information for PT-2385, inhibitor

Product References and Citations for PT-2385, inhibitor

Other Notes