VU6015929 Inhibitor

Name: VU6015929 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5758725
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5758725

VU6015929 is an inhibitor of active dual discoidin domain receptor 1/2 (DDR1/2)(IC50s of 4.67nM and 7.39nM, respectively). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

VU6015929, Inhibitor

Full Product Name

VU6015929

Product Gene Name

VU6015929, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.07%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

485.4

Solubility

DMSO: 250mg/mL (515.01mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C24H19F4N5O2

SMILES

Cn1ccc(-c2cncc(CNc3cc(C(=O)Nc4cccc(OC(F)(F)F)c4)ccc3F)c2)n1

Target & IC50

DDR1: ic50 4.67nM
DDR2: ic50 7.39nM

In Vitro

VU6015929 potently blocks collagen-induced DDR1 activation and collagen-IV production, suggesting DDR1 inhibition as an exciting target for antifibrotic therapy[1].

Product Categories/Family for VU6015929, inhibitor

Tyrosine Kinase/Adaptors

Product References and Citations for VU6015929, inhibitor

Jeffries DE, Borza CM, Blobaum AL,et al.Discovery of VU6015929: A Selective Discoidin Domain Receptor 1/2 (DDR1/2) Inhibitor to Explore the Role of DDR1 in Antifibrotic Therapy[1]. ACS Med Chem Lett. 2019 Nov 25 ;11(1):29-33.

Other Notes

Small volumes of VU6015929, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for VU6015929 purchase

MBS5758725 is an inhibitor targeting VU6015929.