SP-13786 Inhibitor

SP-13786 is an inhibitor of fibroblast activation protein (FAP) (IC50 : 3.2nM); also inhibits prolyl oligopeptidase (PREP) (IC50 : 1.8 uM).

Jansen K, Heirbaut L, Verkerk R, et al. Extended Structure-Activity Relationship and Pharmacokinetic Investigation of (4-Quinolinoyl)glycyl-2-cyanopyrrolidine Inhibitors of Fibroblast Activation Protein (FAP)[J]. Journal of Medicinal Chemistry, 2014, 57(7):3053-3074.
Jansen K, Heirbaut L, Verkerk R, et al. Extended Structure-Activity Relationship and Pharmacokinetic Investigation of (4-Quinolinoyl)glycyl-2-cyanopyrrolidine Inhibitors of Fibroblast Activation Protein (FAP)[J]. Journal of Medicinal Chemistry, 2014, 57(7):3053-3074.
Gunderson A J, Yamazaki T, Mccarty K, et al. Blockade of fibroblast activation protein in combination with radiation treatment,in murine models of pancreatic adenocarcinoma[J]. Plos One, 2019, 14(2).
Gunderson A J, Yamazaki T, Mccarty K, et al. Blockade of fibroblast activation protein in combination with radiation treatment,in murine models of pancreatic adenocarcinoma[J]. Plos One, 2019, 14(2).

Small volumes of SP-13786, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5758752 is an inhibitor targeting SP-13786.