PBD-150 Inhibitor

PBD-150 is an inhibitor of human glutaminyl cyclase (hQC) Y115E-Y117E variant(ki : 490nM)

Huang, K.-F, Liaw, S.-S, Huang, W.-L,et al. Structures of Human Golgi-resident Glutaminyl Cyclase and Its Complexes with Inhibitors Reveal a Large Loop Movement upon Inhibitor Binding[J]. Journal of Biological Chemistry, 286(14):12439-12449.
Huang, K.-F, Liaw, S.-S, Huang, W.-L,et al. Structures of Human Golgi-resident Glutaminyl Cyclase and Its Complexes with Inhibitors Reveal a Large Loop Movement upon Inhibitor Binding[J]. Journal of Biological Chemistry, 286(14):12439-12449.
Dipisa F, Pozzi C, Benvenuti M, et al. The soluble Y115E-Y117E variant of human glutaminyl cyclase is a valid target for X-ray andnMR screening of inhibitors against Alzheimer disease[J]. Acta Crystallographica, 2015, 71(8):986-992.
Dipisa F, Pozzi C, Benvenuti M, et al. The soluble Y115E-Y117E variant of human glutaminyl cyclase is a valid target for X-ray andnMR screening of inhibitors against Alzheimer disease[J]. Acta Crystallographica, 2015, 71(8):986-992.

Small volumes of PBD-150, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5758767 is an inhibitor targeting PBD-150.