VPS341 Inhibitor – VPS34 1 (Compound 19, PIK-III Analogue)

Name: VPS341 Inhibitor; VPS34 1 (Compound 19, PIK-III Analogue); MyBioSource
Brand: MyBioSource
SKU: MBS5758802
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5758802

VPS34 inhibitor 1 (Compound 19, PIK-III analogue) is a potent and selective inhibitor of VPS34(IC50 : 15nM) More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

VPS34 1 (Compound 19, PIK-III analogue) (VPS341), Inhibitor

Full Product Name

VPS34 inhibitor 1 (Compound 19, PIK-III analogue)

Product Gene Name

VPS341, inhibitor

Product Synonym Names

PIK-III analogue

Form/Format

Solid. Powder

Purity/Purification

98.44%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

391.47

Solubility

DMSO: 78mg/mL (199.25mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C21H25N7O

SMILES

CC(C)(O)CNc1ncc(-c2ccnc(Nc3ccncc3)n2)c(CC2CC2)n1

CAS Number

1383716-46-8

Target & IC50

VPS34: ic50 15nM

Cell Research

Cell lines: U2OS cells.Concentrations: 0, 1, 5, 10uM. Incubation Time: 24 hours.Method: For inhibitor assay, cells are plated and the following day when cells had reached 90%, are treated with dimethyl sulfoxide (DMSO, vehicle) or the indicated concentration of PIK-III or Compound 19, both dissolved in DMSO. 24 hours later, cells are lysed in RIPA supplemented with 1% SDS and mini-EDTA protease inhibitors, homogenized by passage through a Qiashredder column and the protein is quantified by DC Lowry protein assay.

In Vitro

VPS34 inhibitor 1 (Compound 19, PIK-III analogue) is extraordinarily selective over other lipid and protein kinases. The ability of compound 19 to prevent the degradation of autophagy substrates p62, NCOA4, NBR1, NDP52, and FTH1 is similar to PIK-III. In addition, treatment of cells with compound 19 leads to an increase in the lipidated and nonlipidated forms of LC3 similar to previous reports using PIK-III.

Product Categories/Family for VPS341, inhibitor

PI3K/Akt/mTOR signaling; PI3K

Product References and Citations for VPS341, inhibitor

Honda A, Harrington E, Cornella-Taracido I, et al. Potent, Selective, and Orally Bioavailable Inhibitors of VPS34 Provide Chemical Tools to Modulate Autophagy in Vivo[J]. ACS Medicinal Chemistry Letters, 2015, 7(1).

Other Notes

Small volumes of VPS341, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for VPS341 purchase

MBS5758802 is an inhibitor targeting VPS341. Also known as VPS34 inhibitor 1 (Compound 19, PIK-III analogue).