YM976 Inhibitor

MBS5758808 is an inhibitor targeting YM976. YM976 is an orally active PDE4 inhibitor (IC50:2.2nM)

Aoki M, Kobayashi M, Ishikawa J, et al. A Novel Phosphodiesterase Type 4 Inhibitor, YM976 (4-(3-Chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one), with Little Emetogenic Activity[J]. Journal of Pharmacology & Experimental Therapeutics, 2000, 295(1):255-260.
Aoki M, Kobayashi M, Ishikawa J, et al. A Novel Phosphodiesterase Type 4 Inhibitor, YM976 (4-(3-Chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one), with Little Emetogenic Activity[J]. Journal of Pharmacology & Experimental Therapeutics, 2000, 295(1):255-260.
Aoki M, Yamamoto S, Kobayashi M, et al. Antiasthmatic effect of YM976, a novel PDE4 inhibitor, in guinea pigs[J]. Journal of Pharmacology and Experimental Therapeutics, 2001, 297(1):165-173.
Aoki M, Yamamoto S, Kobayashi M, et al. Antiasthmatic effect of YM976, a novel PDE4 inhibitor, in guinea pigs[J]. Journal of Pharmacology and Experimental Therapeutics, 2001, 297(1):165-173.

Small volumes of YM976, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.