Oncrasin 1 Inhibitor

Name: Oncrasin 1 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5758856
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5758856

Oncrasin 1 is a potent inhibitor of anticancer that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Oncrasin 1, Inhibitor

Full Product Name

Oncrasin 1

Form/Format

Solid. Powder

Purity/Purification

99.68%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

269.73

Solubility

DMSO: 43mg/mL (159.42mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C16H12ClNO

SMILES

O=Cc1cn(Cc2ccc(Cl)cc2)c2ccccc12

CAS Number

75629-57-1

Target & IC50

K-Ras

In Vitro

In vivo administration of oncrasin-1 suppressed the growth of K-ras mutant human lung tumor xenografts by >70% and prolonged the survival of nude mice bearing these tumors, without causing detectable toxicity[1].

Product Categories/Family for Oncrasin 1, inhibitor

MAPK; Ras; GPCR/G Protein

Product References and Citations for Oncrasin 1, inhibitor

Guo W, Wu S, Liu J, et al. Identification of a Small Molecule with Synthetic Lethality for K-Ras and Protein Kinase C Iota[J]. Cancer Research, 2008, 68(18):7403-7408.
Guo W, Wu S, Liu J, et al. Identification of a Small Molecule with Synthetic Lethality for K-Ras and Protein Kinase C Iota[J]. Cancer Research, 2008, 68(18):7403-7408.
Guo W, Wu S, Wang L, et al. Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1)[J]. Molecular Cancer Therapeutics, 2009, 8(2):441-448.
Guo W, Wu S, Wang L, et al. Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1)[J]. Molecular Cancer Therapeutics, 2009, 8(2):441-448.

Other Notes

Small volumes of Oncrasin 1, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Oncrasin 1 purchase

MBS5758856 is an inhibitor targeting Oncrasin 1.