LC3-mHTT-IN-AN1 Inhibitor

Name: LC3-mHTT-IN-AN1 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5758911
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5758911

LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B. LC3-mHTT-IN-AN1 targeted mHTT to autophagosomes reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD)… More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

LC3-mHTT-IN-AN1 (LC3-mHTT-IN-AN1 ), Inhibitor

Full Product Name

LC3-mHTT-IN-AN1

Product Gene Name

LC3-mHTT-IN-AN1 , inhibitor

Product Synonym Names

LC3-mHTT-IN-AN1

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

411.04

Solubility

DMSO: 120mg/mL (291.94mM) Need ultrasonic
H2O: <0.1mg/mL (insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C15H9Br2NO3

SMILES

Oc1cc(\C=C2/C(=O)Nc3ccc(Br)cc23)cc(Br)c1O

CAS Number

486443-73-6

Target & IC50

mHTT-LC3 Linker Compound

In Vitro

LC3-mHTT-IN-AN1 targeted mHTT to autophagosomes, reduced mHTT levels in an allele-selective manner, and rescued disease-relevant phenotypes in cells and in vivo in fly and mouse models of Huntington's disease.

Product Categories/Family for LC3-mHTT-IN-AN1 , inhibitor

Autophagy

Product References and Citations for LC3-mHTT-IN-AN1 , inhibitor

Li Z, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Nov;575(7781):203-209.

Other Notes

Small volumes of LC3-mHTT-IN-AN1 , inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LC3-mHTT-IN-AN1 purchase

MBS5758911 is an inhibitor targeting LC3-mHTT-IN-AN1 . Also known as LC3-mHTT-IN-AN1.