Guan-fu base A Inhibitor

Name: Guan-fu base A Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5759003
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5759003

Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20uM in HLMs; Ki: 0.37 uM for rCYP2D6). It also inhibits HERG channel current. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Guan-fu base A, Inhibitor

Full Product Name

Guan-fu base A

Product Synonym Names

Guanfu base A

Form/Format

Solid. Powder

Purity/Purification

99.71%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

429.50

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C24H31NO6

SMILES

CC(=O)O[C@H]1C[C@@]2(CN3[C@@H]4[C@H]2[C@]5(C1)[C@H]3[C@]6(C([C@H]7[C@H]([C@@H]5[C@]6(C4)CC7=C)O)OC(=O)C)O)C

CAS Number

1394-48-5

Target & IC50

CYP2D6: ic50 0.37uM (Ki, cell free)
HERG channel

In Vitro

Beagle dogs treated intravenously with Dextromethorphan (2mg/mL) after pretreatment with Guanfu base A injection shows reduced CYP2D metabolic activity, with the Cmax of dextrorphan being one-third that of the saline-treated group and area under the plasma concentration-time curve half that of the saline-treated group [1].

Product Categories/Family for Guan-fu base A, inhibitor

Metabolism; P450; Membrane Transporter/Ion Channel

Product References and Citations for Guan-fu base A, inhibitor

Sun J, et al. Guanfu base A, an antiarrhythmic alkaloid of Aconitum coreanum, Is a CYP2D6 inhibitor of human, monkey, and dog isoforms. Drug Metab Dispos. 2015 May;43(5):713-24.
Sun J, et al. Guanfu base A, an antiarrhythmic alkaloid of Aconitum coreanum, Is a CYP2D6 inhibitor of human, monkey, and dog isoforms. Drug Metab Dispos. 2015 May;43(5):713-24.
Huang X, et al. Comparative effects of Guanfu base A and Guanfu base G on HERG K+ channel. J Cardiovasc Pharmacol. 2012 Jan;59(1):77-83.
Huang X, et al. Comparative effects of Guanfu base A and Guanfu base G on HERG K+ channel. J Cardiovasc Pharmacol. 2012 Jan;59(1):77-83.

Other Notes

Small volumes of Guan-fu base A, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Guan-fu base A purchase

MBS5759003 is an inhibitor targeting Guan-fu base A.