VU0119498 Inhibitor

VU0119498 is a M1 muscarinic receptor agonist (EC50 = 3.1uM) and pan mAChR M3, M5 positive allosteric modulator (PAM), and is a neuroprotective agent.

Lu Zhu,et al. Allosteric Modulation of beta-Cell M 3 Muscarinic Acetylcholine Receptors Greatly Improves Glucose Homeostasis in Lean and Obese Mice.Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18684-18690.
Lu Zhu, Mario Rossi,et al. Allosteric Modulation of beta-Cell M 3 Muscarinic Acetylcholine Receptors Greatly Improves Glucose Homeostasis in Lean and Obese Mice.Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18684-18690.
Lu Zhu, Mario Rossi,et al. Allosteric Modulation of beta-Cell M 3 Muscarinic Acetylcholine Receptors Greatly Improves Glucose Homeostasis in Lean and Obese Mice.Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18684-18690.
Bridges T M, Kennedy J P, Cho H P, et al. Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M5 PAM[J]. Bioorganic & Medicinal Chemistry Letters, 2010, 20(2):558-562.
Thomas M Bridges,et al.Heterobiaryl and Heterobiaryl Ether Derived M5 Positive Allosteric Modulators. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5617-2
Thomas M Bridges,et al.Heterobiaryl and Heterobiaryl Ether Derived M5 Positive Allosteric Modulators. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5617-22.

Small volumes of VU0119498, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5759037 is an inhibitor targeting VU0119498.