PNU112455A Inhibitor – PNU 112455a

PNU 112455A is an ATP site competetive inhibitor of CDK2 and CDK5,binds to the ATP site of CDK2 and CDK5 with Kms of 3.6 and 3.2uM, respectively.

Clare PM, et al. The cyclin-dependent kinases cdk2 and cdk5 act by a random, anticooperative kinetic mechanism. J Biol Chem. 2001 Dec 21;276(51):48292-9.
Clare PM, et al. The cyclin-dependent kinases cdk2 and cdk5 act by a random, anticooperative kinetic mechanism. J Biol Chem. 2001 Dec 21;276(51):48292-9.
Iii E A M, Beaman-Hall C M, Mathur A, et al. Roscovitine, olomoucine, purvalanol: inducers of apoptosis in maturing cerebellar granule neurons[J]. Biochemical Pharmacology, 2004, 67(10):1947-1964.
Iii E A M, Beaman-Hall C M, Mathur A, et al. Roscovitine, olomoucine, purvalanol: inducers of apoptosis in maturing cerebellar granule neurons[J]. Biochemical Pharmacology, 2004, 67(10):1947-1964.

Small volumes of PNU112455A, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5759041 is an inhibitor targeting PNU112455A. Also known as PNU 112455A.