Cimicifugoside Inhibitor

Cimicifugoside, a triterpenoid isolated from Cimicifuga simplex, is a novel specific nucleoside transport inhibitor. It also shows immunosuppressive activity.

Yawata A, et al. Inhibition of nucleoside transport and synergistic potentiation of methotrexate cytotoxicity by cimicifugoside, a triterpenoid from Cimicifuga simplex. Eur J Pharm Sci. 2009 Nov 5;38(4):355-61.
Yawata A, et al. Inhibition of nucleoside transport and synergistic potentiation of methotrexate cytotoxicity by cimicifugoside, a triterpenoid from Cimicifuga simplex. Eur J Pharm Sci. 2009 Nov 5;38(4):355-61.
Hemmi H, et al. The immune response of splenic lymphocytes after cimicifugoside treatment,in vitro and pretreatment,in vivo. J Pharmacobiodyn. 1980 Dec;3(12):643-8.
Hemmi H, et al. The immune response of splenic lymphocytes after cimicifugoside treatment,in vitro and pretreatment,in vivo. J Pharmacobiodyn. 1980 Dec;3(12):643-8.

Small volumes of Cimicifugoside, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5759110 is an inhibitor targeting Cimicifugoside.