ONO-7475 Inhibitor

Name: ONO-7475 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5759134
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5759134

ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ONO-7475, Inhibitor

Full Product Name

ONO-7475

Product Gene Name

ONO-7475, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.33%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

562.57

Solubility

DMSO: 100mg/mL (177.76mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C32H26N4O6

SMILES

COc1cc2nccc(Oc3ccc(NC(=O)c4cc5C(=O)CCCc5n(-c5ccccc5)c4=O)nc3)c2cc1OC

CAS Number

1646839-59-9

Target & IC50

Mer

Cell Research

Cell Line:High AXL-expressing cell: PC-9,HCC4011,H1975, PC-9KGR cells. Low AXL-expressing cell: HCC827, HCC4006, and H3255 cells. Concentration:0.0001uM; 0.001uM; 0.01uM; 0.1uM; 1uM. Incubation Time:72 hours[1].

Product Categories/Family for ONO-7475, inhibitor

Tyrosine Kinase/Adaptors; TAM Receptor

Product References and Citations for ONO-7475, inhibitor

Ruvolo PP, et al. Anexelekto/MER tyrosine kinase inhibitor ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanisms.Haematologica. 2017 Dec;102(12):2048-2057.
Ruvolo PP, et al. Anexelekto/MER tyrosine kinase inhibitor ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanisms.Haematologica. 2017 Dec;102(12):2048-2057.
Okura N, et al. ONO-7475, a Novel AXL Inhibitor, Suppresses the Adaptive Resistance to Initial EGFR-TKI treatment,in EGFR-Mutated Non-Small Lung Cancer.Clin Cancer Res. 2020 Jan 17.
Okura N, et al. ONO-7475, a Novel AXL Inhibitor, Suppresses the Adaptive Resistance to Initial EGFR-TKI treatment,in EGFR-Mutated Non-Small Lung Cancer.Clin Cancer Res. 2020 Jan 17.

Other Notes

Small volumes of ONO-7475, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ONO-7475 purchase

MBS5759134 is an inhibitor targeting ONO-7475.