SRT1460 Inhibitor

Name: SRT1460 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5759151
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5759151

MBS5759151 is an inhibitor targeting SRT1460. SRT1460 is a SIRT1 activator. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SRT1460, Inhibitor

Full Product Name

SRT1460

Product Gene Name

SRT1460, inhibitor

Form/Format

Solid. Powder

Purity/Purification

97.62%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

507.6

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C26H29N5O4S

SMILES

COc1cc(cc(OC)c1OC)C(=O)Nc1ccccc1-c1cn2c(CN3CCNCC3)csc2n1

CAS Number

925432-73-1

Target & IC50

SIRT1

Cell Research

Patu8988t (pancreatic cancer cells), Panc-1 (pancreatic cancer cells), SU86.86 (pancreatic cancer cells), HPDE cells. Concentration:2uM, 4uM, 6uM. Incubation Time:72 hours[1]

In Vitro

SRT1460 inhibited cell growth and survival of pancreatic cancer cells[1].

Product Categories/Family for SRT1460, inhibitor

Chromatin/Epigenetic; Sirtuin; DNA Damage/DNA Repair

Product References and Citations for SRT1460, inhibitor

Chini CC, Espindola-Netto JM, Mondal G,et al. SIRT1-Activating Compounds (STAC) Negatively Regulate Pancreatic Cancer Cell Growth and Viability Through a SIRT1 Lysosomal-Dependent Pathway[J]. clinical cancer research, 2016, 22(10):2496-2507.
Chini CC, Espindola-Netto JM, Mondal G,et al. SIRT1-Activating Compounds (STAC) Negatively Regulate Pancreatic Cancer Cell Growth and Viability Through a SIRT1 Lysosomal-Dependent Pathway[J]. clinical cancer research, 2016, 22(10):2496-2507.
SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1.J Biol Chem. 2010 Mar 12;285(11):8340-51.
SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1.J Biol Chem. 2010 Mar 12;285(11):8340-51.Pacholec M, Bleasdale JE, Chrunyk B,et al.

Other Notes

Small volumes of SRT1460, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

SRT1460 Inhibitor

Product Overview

Product Categories/Family for SRT1460, inhibitor

Structure of SRT1460, inhibitor

Related Product Information for SRT1460, inhibitor

Product References and Citations for SRT1460, inhibitor

Other Notes