Mitochonic acid 5 Inhibitor

Name: Mitochonic acid 5 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5759170
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5759170

Mitochonic acid 5 is a derivative of the plant hormone indole-3-acetic acid. Mitochonic acid 5 binds mitochondria and ameliorates renal tubular and cardiac myocyte damage.It has been shown to improve survival of fibroblasts from patients with mitochondrial… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Mitochonic acid 5, Inhibitor

Full Product Name

Mitochonic acid 5

Product Synonym Names

MA-5

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

329.30

Solubility

DMSO: 95mg/mL (288.49mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C18H13F2NO3

SMILES

OC(=O)C(CC(=O)C1=C(F)C=C(F)C=C1)C1=CNC2=CC=CC=C12

CAS Number

1354707-41-7

Target & IC50

Mitochondrial Metabolism

Cell Research

TNFalpha was used to induce inflammatory injury in mouse microglial BV-2 cells with and without prior MA-5 treatment, Cellular apoptosis was assessed using the MTT and TUNEL assays. Mitochondrial functions were evaluated via mitochondrial membrane potential JC-1 staining, ROS flow cytometry analysis, mPTP opening assessment, and immunofluorescence of cyt-c. Mitophagy was examined using western blots and immunofluorescence. The pathways analysis was carried out using western blots and immunofluorescence with a pathway blocker[1].

Product Categories/Family for Mitochonic acid 5, inhibitor

Metabolic Enzyme/Protease

Product References and Citations for Mitochonic acid 5, inhibitor

Lei Q, et al. Mitochonic acid 5 activates the MAPK-ERK-yap signaling pathways to protect mouse microglial BV-2 cells against TNFalpha-induced apoptosis via increased Bnip3-related mitophagy. Cell Mol Biol Lett. 2018 Apr 5;23:14.
Lei Q, et al. Mitochonic acid 5 activates the MAPK-ERK-yap signaling pathways to protect mouse microglial BV-2 cells against TNFalpha-induced apoptosis via increased Bnip3-related mitophagy. Cell Mol Biol Lett. 2018 Apr 5;23:14.
Suzuki T, et al. Mitochonic Acid 5 Binds Mitochondria and Ameliorates Renal Tubular and Cardiac Myocyte Damage. J Am Soc Nephrol. 2016 Jul;27(7):1925-32.
Suzuki T, et al. Mitochonic Acid 5 Binds Mitochondria and Ameliorates Renal Tubular and Cardiac Myocyte Damage. J Am Soc Nephrol. 2016 Jul;27(7):1925-32.

Other Notes

Small volumes of Mitochonic acid 5, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Mitochonic acid 5 purchase

MBS5759170 is an inhibitor targeting Mitochonic acid 5.