ML188 Inhibitor

ML188 is a selective noncovalent SARS-CoV 3CLpro inhibitor(IC50 : 1.5uM), with moderate MW and good enzyme and antiviral inhibitory activity.

Jacobs J, Grum-Tokars V, Zhou Y, et al. Discovery, Synthesis, And Structure-Based Optimization of a Series of N -( tert -Butyl)-2-( N -arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease[J]. Journal of Medicinal Chemistry, 2013, 56(2):534-546.
Jacobs J, Grum-Tokars V, Zhou Y, et al. Discovery, Synthesis, And Structure-Based Optimization of a Series of N -( tert -Butyl)-2-( N -arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease[J]. Journal of Medicinal Chemistry, 2013, 56(2):534-546.
Michael Berry, Burtram Fielding, Junaid Gamieldien.Human Coronavirus OC43 3CL Protease and the Potential of ML188 as a Broad-Spectrum Lead Compound: Homology Modelling and Molecular Dynamic Studies[J]. BMC Struct Biol. 2015 Apr 28;15:8.
Michael Berry, Burtram Fielding, Junaid Gamieldien.Human Coronavirus OC43 3CL Protease and the Potential of ML188 as a Broad-Spectrum Lead Compound: Homology Modelling and Molecular Dynamic Studies[J]. BMC Struct Biol. 2015 Apr 28;15:8.

Small volumes of ML188, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5759175 is an inhibitor targeting ML188.