JCN037 Inhibitor

Name: JCN037 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5759229
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5759229

JCN037 is potent, non-covalent and brain-penetrant inhibitor of EGFR(EGFR, p-wtEGFR and pEGFRvI¢ with IC50 of 2.49nM, 3.95nM, 4.48nM, respectively). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

JCN037, Inhibitor

Full Product Name

JCN037

Product Gene Name

JCN037, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

376.18

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C16H11BrFN3O2

SMILES

Fc1c(Br)cccc1Nc1ncnc2cc3OCCOc3cc12

CAS Number

2305154-31-6

Target & IC50

EGFR: ic50 2.49nM
p-wtEGFR: ic50 3.95nM
pEGFRvIII: ic50 4.48nM

In Vitro

Relative to the conventional EGFR TKIs erlotinib and lapatinib, JCN037 displayed potent activity against EGFR amplified/mutant patient-derived cell cultures, significant BBB penetration (2:1 brain-to-plasma ratio), and superior efficacy in an EGFR-driven orthotopic glioblastoma xenograft model.

Product Categories/Family for JCN037, inhibitor

Angiogenesis; EGFR; JAK/STAT signaling; Tyrosine Kinase/Adaptors

Product References and Citations for JCN037, inhibitor

Jonathan E. Tsang, et al. Development of a Potent Brain-Penetrant EGFR Tyrosine Kinase Inhibitor against Malignant Brain Tumors. ACS Med. Chem. Lett. 2020. May 1.

Other Notes

Small volumes of JCN037, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for JCN037 purchase

MBS5759229 is an inhibitor targeting JCN037.