ASP4132 Inhibitor

ASP4132 is an orally active AMPK activator (EC50 : 18nM), has anti-cancer activity.

Kazuyuki Kuramoto, Yuki Sawada, Tomohiro Yamada,et al.Novel Indirect AMP-Activated Protein Kinase Activators: Identification of a Second-Generation Clinical Candidate with Improved Physicochemical Properties and Reduced hERG Inhibitory Activity.Chem Pharm Bull (Tokyo). 2020;68(5):452-465.
Kazuyuki Kuramoto, Yuki Sawada, Tomohiro Yamada,et al.Novel Indirect AMP-Activated Protein Kinase Activators: Identification of a Second-Generation Clinical Candidate with Improved Physicochemical Properties and Reduced hERG Inhibitory Activity.Chem Pharm Bull (Tokyo). 2020;68(5):452-465.
Kazuyuki Kuramoto, et al. Development of a Potent and Orally Active Activator of Adenosine Monophosphate-Activated Protein Kinase (AMPK), ASP4132, as a Clinical Candidate for the treatment,of Human Cancer. Bioorg Med Chem. 2020 Mar 1;28(5):115307.
Kazuyuki Kuramoto, et al. Development of a Potent and Orally Active Activator of Adenosine Monophosphate-Activated Protein Kinase (AMPK), ASP4132, as a Clinical Candidate for the treatment,of Human Cancer. Bioorg Med Chem. 2020 Mar 1;28(5):115307.

Small volumes of ASP4132, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5759230 is an inhibitor targeting ASP4132.