NPS2390 Inhibitor – Small Molecule Inhibitor

Name: NPS2390 Inhibitor; Small Molecule Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5759252
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5759252

NPS2390 is a first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 (IC50 of 5.2 and 82nM, respectively) More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NPS2390, Inhibitor

Full Product Name

NPS2390

Product Gene Name

NPS2390, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

307.40

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C19H21N3O

SMILES

O=C(NC12CC3CC(CC(C3)C1)C2)c1cnc2ccccc2n1

CAS Number

226878-01-9

Target & IC50

mGluR1: ic50 5.2nM
mGluR5: ic50 82nM

In Vitro

Treatment of NPS2390 was conducive to inhibit the proliferation and reverse phenotypic modulation of PASMCs by regulating autophagy levels.

Product Categories/Family for NPS2390, inhibitor

Neuroscience

Product References and Citations for NPS2390, inhibitor

Peng X, Wei C, Li H Z, et al. NPS2390, a Selective Calcium-sensing Receptor Antagonist Controls the Phenotypic Modulation of Hypoxic Human Pulmonary Arterial Smooth Muscle Cells by Regulating Autophagy[J]. Journal of Translational Internal Medicine, 2019, 7(2):59-68.

Other Notes

Small volumes of NPS2390, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NPS2390 purchase

MBS5759252 is an inhibitor targeting NPS2390.