RA-9 Inhibitor

Name: RA-9 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5759259
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5759259

RA-9 is a potent and selective proteasome-associated inhibitor of deubiquitinating enzymes (DUBs), with favorable toxicity profile and anticancer activity. RA-9 selectively induces apoptosis in ovarian cancer cell lines. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

RA-9, Inhibitor

Full Product Name

RA-9

Product Gene Name

RA-9, inhibitor

Form/Format

Solid. Powder

Purity/Purification

99.31%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

365.34

Solubility

DMSO: 4mg/mL (10.95mM) ultrasonic and warming and heat to 80 degree C
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C19H15N3O5

SMILES

[O-][N+](=O)c1ccc(\C=C2/CNC\C(=C/c3ccc(cc3)[N+]([O-])=O)C2=O)cc1

CAS Number

919091-63-7

Target & IC50

Apoptosis
deubiquitinating enzymes (DUBs)

In Vitro

In vivo treatment with RA-9 retards tumor growth, increases overall survival, and was well tolerated by the host.

Product Categories/Family for RA-9, inhibitor

Apoptosis; Cell Cycle/DNA Damage

Product References and Citations for RA-9, inhibitor

Coughlin K, Anchoori R, Iizuka Y, et al. Small-molecule RA-9 inhibits proteasome-associated DUBs and ovarian cancer in vitro and in vivo via exacerbating unfolded protein responses.[J]. Clinical Cancer Research An Official Journal of the American Association for Cancer Research, 2014, 20(12):3174-86.

Other Notes

Small volumes of RA-9, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RA-9 purchase

MBS5759259 is an inhibitor targeting RA-9.