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RETV804M-IN-1 Inhibitor – RET V804M-in-1

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5759261

MBS5759261 is an inhibitor targeting RETV804M-IN-1. Also known as RET V804M-IN-1. RET V804M-IN-1 is a wt-RET -selective RETV804M kinase inhibitors(IC50 = 20nM). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
RET V804M-IN-1 (RETV804M-IN-1), Inhibitor
Full Product Name
RET V804M-IN-1
Product Gene Name
RETV804M-IN-1, inhibitor
Product Synonym Names
LUN09945; RETV804M kinase inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
344.37
Solubility
DMSO: 120mg/ml (348.46mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C19H16N6O
SMILES
NC(=O)C1=CC=C(C=C1)C1=C2N=C(NCC3=CC=CN=C3)C=CN2N=C1
CAS Number
2414909-94-5
Target & IC50
RETV804M: ic50 0.42uM (kd)

Product Categories/Family for RETV804M-IN-1, inhibitor

Apoptosis; c-RET; Tyrosine Kinase/Adaptors

Structure of RETV804M-IN-1, inhibitor

RETV804M-IN-1 Inhibitor – Cat# MBS5759261

Product References and Citations for RETV804M-IN-1, inhibitor

Rebecca Newton, et al. Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RET V804M Kinase. ACS Med Chem Lett. 2020 Feb 28;11(4):497-505.

Other Notes

Small volumes of RETV804M-IN-1, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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