SC-43 Inhibitor

Name: SC-43 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5759272
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5759272

SC-43 is a potent and orally active agonist of SHP-1 (PTPN6). SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis, and with anti-fibrotic and anticancer effects. More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SC-43, Inhibitor

Full Product Name

SC-43

Product Gene Name

SC-43, inhibitor

Form/Format

Solid. Powder

Purity/Purification

99.26%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

431.80

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C21H13ClF3N3O2

SMILES

FC(F)(F)c1cc(NC(=O)Nc2cccc(Oc3ccc(cc3)C#N)c2)ccc1Cl

CAS Number

1400989-25-4

Target & IC50

SHP-1
STAT3
apoptosis

In Vitro

In vivo assay revealed that SC-43 exhibited xenograft tumor growth inhibition, p-STAT3 reduction and SHP-1 activity elevation[1].

Product Categories/Family for SC-43, inhibitor

Phosphatase; Metabolic Enzyme/Protease; JAK/STAT signaling; Stem Cells; Apoptosis

Product References and Citations for SC-43, inhibitor

Ming-Hung Hu, et al. Targeting SHP-1-STAT3 signaling: A promising therapeutic approach for the treatment,of cholangiocarcinoma. Oncotarget. 2017 May 10;8(39):65077-65089.
Ming-Hung Hu, et al. Targeting SHP-1-STAT3 signaling: A promising therapeutic approach for the treatment,of cholangiocarcinoma. Oncotarget. 2017 May 10;8(39):65077-65089.
Tung-Hung Su, et al. Src-homology protein tyrosine phosphatase-1 agonist, SC-43, reduces liver fibrosis. Sci Rep. 2017 May 11;7(1):1728.
Tung-Hung Su, et al. Src-homology protein tyrosine phosphatase-1 agonist, SC-43, reduces liver fibrosis. Sci Rep. 2017 May 11;7(1):1728.

Other Notes

Small volumes of SC-43, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SC-43 purchase

MBS5759272 is an inhibitor targeting SC-43.