GMB-475 Inhibitor

Name: GMB-475 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5759281
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5759281

GMB-475 is a BCR-ABL1 tyrosine kinase degrader based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL).resulting in ubiquitination and subsequent degradation of the… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GMB-475, Inhibitor

Full Product Name

GMB-475

Product Gene Name

GMB-475, inhibitor

Form/Format

Solid. Powder

Purity/Purification

100.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

861.93

Solubility

DMSO: 95mg/mL (110.22mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C43H4F3NOS

SMILES

CC1=C(SC=N1)C1=CC=C(CNC(=O)C2CC(O)CN2C(=O)C(NC(=O)COCCOC2=CC=C(C=C2)C2=CC(NC3=CC=C(OC(F)(F)F)C=C3)=NC=N2)C(C)(C)C)C=C1

Target & IC50

Bcr-Abl1

Product Categories/Family for GMB-475, inhibitor

Angiogenesis; Bcr-Abl; Cytoskeletal Signaling

Product References and Citations for GMB-475, inhibitor

Burslem GM, et al. Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-mediated Targeted Protein Degradation. Cancer Res. 2019 Jul 16. pii: canres.1236.2019.

Other Notes

Small volumes of GMB-475, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GMB-475 purchase

MBS5759281 is an inhibitor targeting GMB-475.