ALOBRESIB Inhibitor

Name: ALOBRESIB Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5759288
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5759288

Alobresib is an inhibitor of BET bromodomain,is an antineoplastic drug candidate. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Alobresib, Inhibitor

Full Product Name

Alobresib

Product Gene Name

Alobresib, inhibitor

Product Synonym Names

Vorolanib; GS-5829

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

437.5

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C26H23N5O2

SMILES

Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(c1ccccn1)c1ccccn1

CAS Number

1637771-14-2

Target & IC50

BET

In Vitro

In comparative in vivo experiments, GS-5829 and/or GS-626510 were found more effective than JQ1 at the concentrations/doses used in decreasing tumor growth in both USC-ARK1 and USC-ARK2 mouse xenograft models

Product Categories/Family for Alobresib, inhibitor

Chromatin/Epigenetic

Product References and Citations for Alobresib, inhibitor

Bonazzoli E, et al. Inhibition of BET Bromodomain Proteins with GS-5829 and GS-626510 in Uterine Serous Carcinoma, a Biologically Aggressive Variant of Endometrial Cancer. Clin Cancer Res. 2018 Oct 1;24(19):4845-4853.

Other Notes

Small volumes of Alobresib, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Alobresib purchase

MBS5759288 is an inhibitor targeting Alobresib.