TLR4-IN-C34 Inhibitor

TLR4-IN-C34 is an inhibitor of TLR4, and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis

Neal MD, et al. Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. PLoS One. 2013 Jun 12;8(6):e65779.
Neal MD, et al. Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. PLoS One. 2013 Jun 12;8(6):e65779.
Adegoke E O, Adeniran S O, Zeng Y, et al. Pharmacological inhibition of TLR4/NF-kappaB with TLR4-IN-C34 attenuated microcystin-leucine arginine toxicity in bovine Sertoli cells[J]. Journal of Applied Toxicology, 2019.
Adegoke E O, Adeniran S O, Zeng Y, et al. Pharmacological inhibition of TLR4/NF-kappaB with TLR4-IN-C34 attenuated microcystin-leucine arginine toxicity in bovine Sertoli cells[J]. Journal of Applied Toxicology, 2019.

Small volumes of TLR4-IN-C34, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5759296 is an inhibitor targeting TLR4-IN-C34.