THPP-1 Inhibitor

Name: THPP-1 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5759299
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5759299

THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1nM and 1.3nM for human and rat PDE10A, respectively). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

THPP-1, Inhibitor

Full Product Name

THPP-1

Product Gene Name

THPP-1, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

464.9

Solubility

DMSO: 31mg/mL (66.68mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C23H21ClN6O3

SMILES

COCCOC1=C2CN(CCC2=NC(=N1)C1=CC=C(Cl)N=C1)C(=O)C1=C2C=CC=CN2C=N1

CAS Number

1257051-63-0

Product Categories/Family for THPP-1, inhibitor

Metabolism

Product References and Citations for THPP-1, inhibitor

Vardigan JD, et al. Behavioral and qEEG effects of the PDE10A inhibitor THPP-1 in a novel rhesus model of antipsychotic activity. Psychopharmacology (Berl). 2016 Jul;233(13):2441-50.
Smith SM, et al. The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkey. Neuropharmacology. 2013 Jan;64:215-23.

Other Notes

Small volumes of THPP-1, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for THPP-1 purchase

MBS5759299 is an inhibitor targeting THPP-1.