Raphin1 acetate Inhibitor

Name: Raphin1 acetate Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5759311
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5759311

Raphin1 acetate is a selective and orally bioavailable regulatory phosphatase PPP1R15B (R15B) inhibitor. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Raphin1 acetate, Inhibitor

Full Product Name

Raphin1 acetate

Form/Format

Solid. Powder

Purity/Purification

99.88%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

291.13

Solubility

DMSO: 40mg/mL (137.4mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C10H12Cl2N4O2

SMILES

CC(O)=O.NC(=N)N\N=C\c1cccc(Cl)c1Cl

CAS Number

2242616-04-0

Target & IC50

R15B-PP1c holophosphatase: ic50 33nM (Kd)

In Vitro

Raphin1 was orally bioavailable, crossed the blood-brain barrier, and demonstrated efficacy in a mouse model of Huntington's disease.

Product Categories/Family for Raphin1 acetate, inhibitor

Phosphatase; Metabolism

Product References and Citations for Raphin1 acetate, inhibitor

Krzyzosiak A, et al. Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B. Cell. 2018 Aug 23;174(5):1216-1228.e19.

Other Notes

Small volumes of Raphin1 acetate, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Raphin1 acetate purchase

MBS5759311 is an inhibitor targeting Raphin1 acetate.