CPYPP Inhibitor

CPYPP is an inhibitor of DOCK2-Rac1 interaction. CPYPP binds to DOCK2 DHR-2 domain and inhibits the guanine nucleotide exchange factor (GEF) activity of DOCK2DHR-2 for Rac1 in a dose-dependent manner(IC50 : 22.8uM). CPYPP also inhibits DOCK180, DOCK5 and less DOCK9

Nishikimi A, et al. Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2. Chem Biol. 2012 Apr 20;19(4):488-97.
Nishikimi A, et al. Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2. Chem Biol. 2012 Apr 20;19(4):488-97.
Ferrandez Y, Zhang W, Peurois F, et al. Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule[J]. entific Reports, 2017, 7(1):14409.
Ferrandez Y, Zhang W, Peurois F, et al. Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule[J]. entific Reports, 2017, 7(1):14409.

Small volumes of CPYPP, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5759316 is an inhibitor targeting CPYPP.