IM156 Inhibitor

IM156 is an orally bioavailable mitochondrial oxidative phosphorylation (OxPhos) inhibitor, with potential antineoplastic activity.

Son J, Cho Y W, Woo Y J, et al. Metabolic Reprogramming by the Excessive AMPK Activation Exacerbates Antigen-Specific Memory CD8 + T Cell Differentiation after Acute Lymphocytic Choriomeningitis Virus Infection[J]. Immune Network, 2019, 19(2).
Son J, Cho Y W, Woo Y J, et al. Metabolic Reprogramming by the Excessive AMPK Activation Exacerbates Antigen-Specific Memory CD8 + T Cell Differentiation after Acute Lymphocytic Choriomeningitis Virus Infection[J]. Immune Network, 2019, 19(2).
Said Izreig, Alexandra Gariepy, Irem Kaymak, et al. Repression of LKB1 by miR-17~92 Sensitizes MYC-Dependent Lymphoma to Biguanide treatment,Cell Rep Med. 2020 May 19;1(2):100014.
Said Izreig, Alexandra Gariepy, Irem Kaymak, et al. Repression of LKB1 by miR-17~92 Sensitizes MYC-Dependent Lymphoma to Biguanide treatment,Cell Rep Med. 2020 May 19;1(2):100014.

Small volumes of IM156, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5759321 is an inhibitor targeting IM156.