• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

A425619 Inhibitor – A 425619

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5759348

MBS5759348 is an inhibitor targeting A425619. Also known as A 425619. A 425619 is a potent TRPV1 antagonist More details

Please Inquire
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
A 425619 (A425619), Inhibitor
Full Product Name
A 425619
Product Gene Name
A425619, inhibitor
Product Synonym Names
1-(4-(TRIFLUOROMETHYL)BENZYL)-3-(ISOQUINOLIN-5-YL)UREA
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
345.3252
Solubility
DMSO: 34.5mg/mL (100mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C18H14F3N3O
SMILES
FC(F)(F)c1ccc(CNC(=O)Nc2cccc3cnccc23)cc1
CAS Number
581809-67-8
Target & IC50
TRPV1: ic50 3-9nM
In Vitro
systemic administration of the TRPV1 antagonist, A-425619, reversed the decrease in digging behavior induced by CFA injection, further confirming the role of TRPV1, expressed by knee neurons, in acute inflammatory joint pain.

Product Categories/Family for A425619, inhibitor

Membrane transporter/Ion channel; TRP/TRPV Channel

Structure of A425619, inhibitor

A425619 Inhibitor – Cat# MBS5759348

Product References and Citations for A425619, inhibitor

Chakrabarti S, Pattison L A, Singhal K, et al. Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner[J]. Neuropharmacology, 2018, 143.

Other Notes

Small volumes of A425619, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000