DMH-25 Inhibitor

Name: DMH-25 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5759355
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5759355

DMH25 is a novel covalent and potent inhibitor of mTOR and shows in vivo antitumor activity against triple-negative breast cancer cells. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

DMH-25, Inhibitor

Full Product Name

DMH-25

Product Gene Name

DMH-25, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

489.941

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C15H8Br3NO3

SMILES

O=[N+](C(C(C1=CC=C(Br)C=C1)O2)=CC3=C2C(Br)=CC(Br)=C3)[O-]

CAS Number

1685280-21-0

Target & IC50

mTOR

In Vitro

In vivo, DHM25 was an efficient inhibitor of growth and metastasis of triple-negative breast cancer cells, paving the way for its clinical application in oncology. Constitutive activation of the PI3K/mTOR signaling pathway contributes to carcinogenesis and metastasis in most, if not all, breast cancers.

Product Categories/Family for DMH-25, inhibitor

PI3K/Akt/mTOR signaling; mTOR

Product References and Citations for DMH-25, inhibitor

amelie, fouque, Delalande O, Jean M, et al. A Novel Covalent mTOR Inhibitor, DHM25, Shows in Vivo Antitumor Activity against Triple-Negative Breast Cancer Cells[J]. Journal of Medicinal Chemistry, 2015:6559-73.

Other Notes

Small volumes of DMH-25, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DMH-25 purchase

MBS5759355 is an inhibitor targeting DMH-25.