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L524-0366 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5759356

MBS5759356 is an inhibitor targeting L524-0366. L524-0366 is a TWEAK-Fn14 signaling cascade inhibitor. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
L524-0366, Inhibitor
Full Product Name
L524-0366
Product Gene Name
L524-0366, inhibitor
Product Synonym Names
[1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
308.787
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C13H13ClN4OS
SMILES
O=C(C1=CN(C2=CC=CC(Cl)=C2)N=N1)N3CCSCC3
CAS Number
951612-19-4
Target & IC50
Fn14
Cell Research
Wild type (WT) and Fn14 knock out (Fn14-/-) mice were subjected to pressure overload [transaortic constriction (TAC)] for 1 or 6 weeks. A subset of WT TAC animals were treated with the Fn14 antagonist L524-0366. Cardiac function was measured by echocardiography. Cardiac fibrosis and macrophage infiltration were quantified using immunohistochemistry and flow cytometry, respectively. Cardiac fibroblasts were isolated for quantifying TWEAK-induced chemokine release.

Structure of L524-0366, inhibitor

L524-0366 Inhibitor – Cat# MBS5759356

Product References and Citations for L524-0366, inhibitor

Unudurthi S D, Nassal D M, Patel N J, et al. Fibroblast growth factor-inducible 14 mediates macrophage infiltration in heart to promote pressure overload-induced cardiac dysfunction[J]. Life ences, 2020, 247:117440.

Other Notes

Small volumes of L524-0366, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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