1-Methyl-2-(Methylthio)iMidazole Inhibitor

1-Methyl-2-(methylthio)imidazole is an impurity of Methimazole, a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine.

Rongjing S, Hepu L, Yue C, et al. Effects of methimazole and propylthiouracil exposure during pregnancy on the risk of neonatal congenital malformations: A meta-analysis[J]. Plos One, 2017, 12(7):e0180108.
Rongjing S, Hepu L, Yue C, et al. Effects of methimazole and propylthiouracil exposure during pregnancy on the risk of neonatal congenital malformations: A meta-analysis[J]. Plos One, 2017, 12(7):e0180108.
Lai, Shih-Wei, Lin,et al. Use of methimazole and risk of acute pancreatitis: A case-control study in Taiwan[J]. Indian journal of pharmacology, 2016.
Lai, Shih-Wei, Lin,et al. Use of methimazole and risk of acute pancreatitis: A case-control study in Taiwan[J]. Indian journal of pharmacology, 2016.

Small volumes of 1-Methyl-2-(Methylthio)iMidazole, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5759397 is an inhibitor targeting 1-Methyl-2-(Methylthio)iMidazole.