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Compound 35 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5759467

Compounds 35 are superior inhibitors of Ebola (Mayinga) and Marburg (Angola) infectious viruses. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Compound 35, Inhibitor
Full Product Name
Compound 35
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
461.52
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C25H30F3N3O2
SMILES
FC(F)(F)c2cc(ccc2N1CCC(C)CC1)NC(=O)c3ccc(cc3)CN4CCOCC4
Target & IC50
Ebola (Mayinga)
Marburg (Angola)
In Vitro
Compounds 35 are superior inhibitors of Ebola (Mayinga) and Marburg (Angola) infectious viruses. Compounds 35 have shown good metabolic stability in plasma and liver microsomes (rat and human), and 32 did not inhibit CYP3A4 nor CYP2C9. These 4-(aminomethyl)benzamides are suitable for further optimization as inhibitors of filovirus entry, with potential to be developed as therapeutic agents for the treatment, and control of Ebola virus infections.

Structure of Compound 35, inhibitor

Compound 35 Inhibitor – Cat# MBS5759467

Product References and Citations for Compound 35, inhibitor

Gaisina I N, Peet N P, Wong L, et al. Discovery and Structural Optimization of 4-(Aminomethyl)benzamides as Potent Entry Inhibitors of Ebola and Marburg Virus Infections[J]. Journal of Medicinal Chemistry, 2020, XXXX(XXX).

Other Notes

Small volumes of Compound 35, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Compound 35 purchase

MBS5759467 is an inhibitor targeting Compound 35.
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