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NNMTi Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5759523

NNMTi is a substrate site-targeting, selective nicotinamide N-methyltransferase (NNMT) inhibitor (IC50 = 1.2uM; 50uM SAM, 100uM NCA) that reduces 3T3-L1 lipogenesis (EC50 = 30uM) and adipocytes 1-methylnicotinamide level (EC50 = 2.3uM) without affecting… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NNMTi, Inhibitor
Full Product Name
NNMTi
Product Gene Name
NNMTi, inhibitor
Product Synonym Names
5-Amino-1-methylquinolinium
Form/Format
Solid. Powder
Purity/Purification
99.93%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
286.11
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C10H11IN2
SMILES
[I-].C[n+]1cccc2c(N)cccc12
CAS Number
42464-96-0

Product References and Citations for NNMTi, inhibitor

Harshini Neelakantan, et al. Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochem Pharmacol. 2019 May;163:481-492.
Benjamin Trinite, Hongtao Zhang, David N Levy,et al.NNRTI-induced HIV-1 protease-mediated cytotoxicity induces rapid death of CD4 T cells during productive infection and latency reversal.Retrovirology. 2019 Jun 26;16(1):17.

Other Notes

Small volumes of NNMTi, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NNMTi purchase

MBS5759523 is an inhibitor targeting NNMTi.
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