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Adalimumab Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5759546

Adalimumab anti-TNF-alpha) is the first fully human recombinant IgG1 monoclonal antibody that specifically targets human TNF-alpha. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Adalimumab, Inhibitor
Full Product Name
Adalimumab
Product Synonym Names
Adalimumab (anti-TNF-alpha); anti-TNF-alpha; LU200134; D2E7
Form/Format
Solid. Powder
Purity/Purification
99.9%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
148000
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
CAS Number
331731-18-1
Target & IC50
TNF-alpha
Cell Research
Objective: Adalimumab induces apoptosis of THP-1 cells Concentrations: 10ug/mL. Incubation Time: 6, 12, 18, 24, 30 hours Method: THP-1 cells (0.5x106) were incubated with anti-FcRI mAb and anti-FcRII mAb, and then cultured with adalimumab, infliximab, huIgG or vehicle (PBS) alone as indicated. LPS (1ug/mL) was added in all culture conditions. Apoptosis was analyzed at different time points by staining with annexin V-FITC and propidium iodide, Apo2.7-PE-conjugated antibody, or 7AAD. Cell lines: THP-1 cells

Product References and Citations for Adalimumab, inhibitor

Mease PJ, et al. Adalimumab: an anti-TNF agent for the treatment,of psoriatic arthritis. Expert Opin Biol Ther. 2005 Nov;5(11):1491-504.
Mease PJ, et al. Adalimumab: an anti-TNF agent for the treatment,of psoriatic arthritis. Expert Opin Biol Ther. 2005 Nov;5(11):1491-504.
Elsakkar MG, et al. Adalimumab ameliorates OVA-induced airway inflammation in mice: Role of CD4(+) CD25(+) FOXP3(+) regulatory T-cells. Eur J Pharmacol. 2016 Sep 5;786:100-108.
Elsakkar MG, et al. Adalimumab ameliorates OVA-induced airway inflammation in mice: Role of CD4(+) CD25(+) FOXP3(+) regulatory T-cells. Eur J Pharmacol. 2016 Sep 5;786:100-108.

Other Notes

Small volumes of Adalimumab, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Adalimumab purchase

MBS5759546 is an inhibitor targeting Adalimumab.
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