Yohimbine Inhibitor

Yohimbine is a nonselective alpha 2-adrenergic receptor (AR) antagonist(IC50 : 0.6uM)

Vay M, Sauter M, Mikus G,et al.Quantification of microdosed oral yohimbine and its major metabolite in human plasma in the picogram range[1]. Bioanalysis. 2019 Aug;11(16):1459-1467.
Vay M, Sauter M, Mikus G,et al.Quantification of microdosed oral yohimbine and its major metabolite in human plasma in the picogram range[1]. Bioanalysis. 2019 Aug;11(16):1459-1467.
Williams K L, Nickel M M, Bielak J T. Baclofen Blocks Yohimbine-Induced Increases in Ethanol-Reinforced Responding in Rats[J]. Pharmacology Biochemistry & Behavior, 2016:S0091305716300223.
Williams K L, Nickel M M, Bielak J T. Baclofen Blocks Yohimbine-Induced Increases in Ethanol-Reinforced Responding in Rats[J]. Pharmacology Biochemistry & Behavior, 2016:S0091305716300223.

Small volumes of Yohimbine, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5759583 is an inhibitor targeting Yohimbine.