Tirucallol Inhibitor

Solid. Powder

98.00%

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

426.72

<1mg/ml refers to the product slightly soluble or insoluble

C30H50O

[H][C@@]12CCC3=C(CC[C@@]4(C)[C@@H](CC[C@]34C)[C@@H](C)CC\C=C(/C)C)[C@@]1(C)CC[C@H](O)C2(C)C

514-46-5

PGE
NO Synthase
NOS

The effect of CMG neutral extract (25-200microg/ml) and Tirucallol (0.1-100microM) on the following: 1) the expression of adhesion molecules (VCAM-1 and ICAM-1) by Cell ELISA and 2) the attachment of monocytes (U937 cells) in TNF-alpha stimulated Human Aortic Endothelial Cells (HAEC) by Adhesion assay. The impact of treatment with CMG neutral extract and Tirucallol in NFkB phosphorylation was also examined by a cell-based ELISA kit. Both CMG extract and Tirucallol inhibit significantly VCAM-1 and ICAM-1 expression in TNF-alpha-stimulated HAEC. They also inhibit significantly the binding of U937 cells to TNF-alpha-stimulated HAEC and attenuate the phosphorylation of NFkB p65.

GPCR/G Protein; Prostaglandin Receptor; Immunology/Inflammation; Immunology/Inflammation